Nonstop route
Des Moines to Chicago nonstop
Yes — United flies DSM to ORD nonstop year-round — about 9× daily.
DSMDes Moines
✈
ORDChicago
9× daily59.5 flights a week
Year-round59.5/wk Jun vs 43.1/wk Jan
$125–$300typical one-way · median $200
299miles nonstop
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Fares are what people actually paid: half of the 1,057 tickets in the US DOT fare survey for this route sold between $125 and $300 one way, median $200. That survey runs a couple of quarters behind, so treat it as the shape of the route's pricing rather than today's quote.
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