Nonstop route
Des Moines to Dallas/Fort Worth nonstop
Yes — American flies DSM to DFW nonstop year-round — about 4× daily.
DSMDes Moines
✈
DFWDallas/Fort Worth
4× daily26.1 flights a week
Year-round26.1/wk Jun vs 24.2/wk Jan
$200–$425typical one-way · median $275
624miles nonstop
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Fares are what people actually paid: half of the 942 tickets in the US DOT fare survey for this route sold between $200 and $425 one way, median $275. That survey runs a couple of quarters behind, so treat it as the shape of the route's pricing rather than today's quote.
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