ORDYear-round
Chicago O'Hare (ORD)
SkyWest · United · American · Republic
9× daily299 mi$125–$300
DSMInternational
Nonstop flights from Des Moines (DSM)
Des Moines International Airport · Des Moines, IA · large airport
DSM has 33 nonstop destinations, including Chicago, Denver and Dallas/Fort Worth. Every route below is a direct flight from Des Moines, busiest first.
33nonstop routes
Yesscheduled service
41.5340° N, 93.6567° W
Direct flights from Des Moines (DSM)
33 nonstop destinations — busiest first, with departures per week
Flight counts are departures actually operated in July 2026, and fares are the middle half of one-way tickets sold in the Q2 2025 survey, both from US DOT filings. Routes without a published fare sample show no price.
DENYear-round
Denver (DEN)
SkyWest · United · Southwest · Frontier
7× daily589 mi$125–$250
DFWYear-round
Dallas Fort Worth (DFW)
American
4× daily624 mi$200–$425
ATLYear-round
Hartsfield Jackson Atlanta (ATL)
Delta
4× daily743 mi$250–$450
PHLSummer only
Philadelphia (PHL)
American · Allegiant · Republic
daily973 mi$150–$325
MDWSummer only
Chicago Midway (MDW)
Southwest
daily306 mi
PHXYear-round
Phoenix Sky Harbor (PHX)
American · Southwest · SkyWest
daily1,149 mi$125–$275
CLTYear-round
Charlotte Douglas (CLT)
American
daily815 mi$175–$350
DCAYear-round
Ronald Reagan Washington National (DCA)
American · Republic
daily897 mi$200–$300
LASYear-round
Harry Reid (LAS)
Southwest · Allegiant
daily1,216 mi$50–$200
LAXYear-round
Los Angeles (LAX)
SkyWest
daily1,447 mi
IAHYear-round
George Bush Intercontinental (IAH)
United
daily802 mi$150–$325
LGAYear-round
LaGuardia (LGA)
Republic
6× weekly1,031 mi$175–$325
BNAYear-round
Nashville (BNA)
Allegiant
5× weekly530 mi$25–$100
PIEYear-round
St. Petersburg Clearwater (PIE)
Allegiant
4× weekly1,126 mi$25–$100
SFBYear-round
Orlando Sanford (SFB)
Allegiant
4× weekly1,124 mi$50–$125
AZAYear-round
Mesa Gateway (AZA)
Allegiant
3× weekly1,137 mi$25–$100
PDXSummer only
Portland (PDX)
Allegiant
3× weekly1,471 mi$75–$125
PGDYear-round
Punta Gorda (PGD)
Allegiant
3× weekly1,206 mi$25–$75
AUSYear-round
Austin Bergstrom (AUS)
Allegiant
2× weekly813 mi$25–$100
BOSSummer only
Boston Logan (BOS)
Allegiant
2× weekly1,165 mi$50–$100
BURSummer only
Hollywood Burbank/Bob Hope (BUR)
Allegiant
2× weekly1,436 mi
EWRSummer only
Newark Liberty (EWR)
Allegiant
2× weekly1,017 mi$25–$100
FLLYear-round
Fort Lauderdale Hollywood (FLL)
Allegiant
2× weekly1,316 mi$25–$100
GUFYear-round
Jack Edwards National (GUF)
Allegiant
2× weekly844 mi
HOUSummer only
William P. Hobby (HOU)
Allegiant
2× weekly825 mi$25–$75
JAXSummer only
Jacksonville (JAX)
Allegiant
2× weekly1,012 mi$25–$75
SNAYear-round
John Wayne Orange County (SNA)
Allegiant
2× weekly1,428 mi$50–$100
VPSSummer only
Destin-Fort Walton Beach (VPS)
Allegiant
2× weekly860 mi$25–$100
MIAWinter only
Miami (MIA)
American · Republic
1× weekly1,327 mi
SRQYear-round
Sarasota Bradenton (SRQ)
Allegiant
1× weekly1,160 mi$25–$75
RSWWinter only
Southwest Florida (RSW)
Allegiant
0× weekly1,236 mi
STLWinter only
St. Louis Lambert (STL)
Southwest
0× weekly259 mi$100–$300
Other airports near Des Moines
Closest IA airports with scheduled service
FOD
Fort Dodge
Fort Dodge Regional Airport
IAScheduled2 routes
ALO
Waterloo
Waterloo Regional Airport
IAScheduled1 routes
CID
Cedar Rapids
The Eastern Iowa Airport
IAScheduled17 routes
MCW
Mason City
Mason City Municipal Airport
IAScheduled1 routes
BRL
Burlington
Southeast Iowa Regional Airport
IAScheduled
No nonstop routes published yet
SUX
Sioux City
Sioux Gateway Airport / Brigadier General Bud Day Field
IAScheduled2 routes