Nonstop route
St Louis to Detroit nonstop
Yes — Delta and Southwest fly STL to DTW nonstop year-round — about 6× daily.
STLSt Louis
✈
DTWDetroit
6× daily39.4 flights a week
Year-round39.4/wk Jun vs 27.5/wk Jan
$125–$325typical one-way · median $175
440miles nonstop
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Fares are what people actually paid: half of the 1,787 tickets in the US DOT fare survey for this route sold between $125 and $325 one way, median $175. That survey runs a couple of quarters behind, so treat it as the shape of the route's pricing rather than today's quote.
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