Nonstop route
Orlando to St. Louis nonstop
Yes — Southwest and Frontier fly MCO to STL nonstop year-round — about 7× daily.
MCOOrlando
✈
STLSt. Louis
7× daily47.6 flights a week
Year-round47.6/wk Jun vs 48.1/wk Jan
$100–$275typical one-way · median $175
882miles nonstop
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Fares are what people actually paid: half of the 5,378 tickets in the US DOT fare survey for this route sold between $100 and $275 one way, median $175. That survey runs a couple of quarters behind, so treat it as the shape of the route's pricing rather than today's quote.
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