Nonstop route
Charlotte to Des Moines nonstop
Yes — American flies CLT to DSM nonstop year-round — about daily.
CLTCharlotte
✈
DSMDes Moines
daily13.8 flights a week
Year-round13.8/wk Jun vs 12/wk Jan
$175–$325typical one-way · median $225
815miles nonstop
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Fares are what people actually paid: half of the 546 tickets in the US DOT fare survey for this route sold between $175 and $325 one way, median $225. That survey runs a couple of quarters behind, so treat it as the shape of the route's pricing rather than today's quote.
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