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Burbank to St. Louis nonstop

Yes — Southwest flies BUR to STL nonstop year-round — about 2× weekly.

BURBurbank
STLSt. Louis

Southwest

2× weekly1.9 flights a week
Year-round1.9/wk Jun vs 2.3/wk Jan
$225–$375typical one-way · median $275
1,583miles nonstop
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Fares are what people actually paid: half of the 505 tickets in the US DOT fare survey for this route sold between $225 and $375 one way, median $275. That survey runs a couple of quarters behind, so treat it as the shape of the route's pricing rather than today's quote.

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