Nonstop route
Detroit to Charlotte nonstop
Yes — American, Delta and Frontier fly DTW to CLT nonstop year-round — about 9× daily.
DTWDetroit
✈
CLTCharlotte
9× daily61.8 flights a week
Year-round61.8/wk Jun vs 59.8/wk Jan
$125–$275typical one-way · median $175
500miles nonstop
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Fares are what people actually paid: half of the 3,647 tickets in the US DOT fare survey for this route sold between $125 and $275 one way, median $175. That survey runs a couple of quarters behind, so treat it as the shape of the route's pricing rather than today's quote.
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