Nonstop route
Charlotte to Syracuse nonstop
Yes — American flies CLT to SYR nonstop year-round — about 3× daily.
CLTCharlotte
✈
SYRSyracuse
3× daily20.5 flights a week
Year-round20.5/wk Jun vs 18.3/wk Jan
$200–$375typical one-way · median $250
603miles nonstop
Affiliate disclosure
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Fares are what people actually paid: half of the 655 tickets in the US DOT fare survey for this route sold between $200 and $375 one way, median $250. That survey runs a couple of quarters behind, so treat it as the shape of the route's pricing rather than today's quote.
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