Nonstop route
Charlotte to San Francisco nonstop
Yes — American flies CLT to SFO nonstop year-round — about 5× daily.
CLTCharlotte
✈
SFOSan Francisco
5× daily32.2 flights a week
Year-round32.2/wk Jun vs 18.5/wk Jan
$225–$400typical one-way · median $275
2,296miles nonstop
Affiliate disclosure
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Fares are what people actually paid: half of the 2,773 tickets in the US DOT fare survey for this route sold between $225 and $400 one way, median $275. That survey runs a couple of quarters behind, so treat it as the shape of the route's pricing rather than today's quote.
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