Nonstop route
Boston to Key West nonstop
Yes — JetBlue flies BOS to EYW nonstop in the winter season only — about 0× weekly.
BOSBoston
✈
EYWKey West
0× weekly0 flights a week
Winter only0/wk Jun vs 8.8/wk Jan
$175–$400typical one-way · median $275
1,373miles nonstop
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Fares are what people actually paid: half of the 308 tickets in the US DOT fare survey for this route sold between $175 and $400 one way, median $275. That survey runs a couple of quarters behind, so treat it as the shape of the route's pricing rather than today's quote.
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